Do your setup. The guys are right, you will want to tune it to see big changes but overall you will notice some changes in the drivability. I currently have skunk 2 stage 1's the old school cams that are a little bigger than CTR's. Not truely tuned but partially with a chipped p28, timing, and cam adjustments while on a dyno.
overall there are flat spots for me simply because I am not tuned properly. Honda ECU's from factory are self tuning so it might be a good idea to run the CTR ecu. Compression is also a factor in getting big resutls. Since the B16A2 is like 10.2 compresion, running a thinner head gasket or milling the head to raise the compression would also ad to the changes you are looking for.
Overall, you could put the cams in with the retainers and springs and call it done, or build up the motor and really see gains.