most people add water/meth to reduce the knock when running crap gas or really aggressive tunes. I'm by no means an expert on water meth setups i have installed two to date and it was some time ago. One was to run more timing and boost the other was to reduce knock. and both cars were tuned for it.
i wasnt the tuner on either install but if i am going by my memory recalls that the a/f ratio in fact did need to be adjusted with the addition of the water/meth setup on both cars we did.